
In another universe,
let's call that Universe Prime...
The Big Bang Theory Season 2, Episode 18

Encryption systems are built
on PRIME numbers.
The Big Bang Theory Season 6, Episode 8

Hint: it's a cube of a cube
of a PRIME.
The Big Bang Theory Season 12, Episode 23

the PRIME minister of England
needs her diaper changed.
The Big Bang Theory Season 12, Episode 6

When he wrote his paper on supersingular
PRIME numbers, how long did it take?
The Big Bang Theory Season 9, Episode 8